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The French may be onto something. Despite a diet filled with rich foods and alcohol, they have a very low incidence of heart disease. How is that possible? The answer seems to lie in Resveratrol—a highly protective plant compound (polyphenol) and antioxidant powerhouse found in the skin of grapes, blueberries, cranberries, pomegranates, red wine and a few other natural sources such as Japanese knotweed.


Resveratrol (Res-vair-uh-traul) is a naturally-occurring powerful antioxidant which protects the body against damage from free radicals. The protective nature of this naturally-occurring antioxidant is not based solely on the wine the French drink, but rather the Resveratrol found in the skin of the grapes the wine is made from. In fact, the longer wine is in contact with the skins of the grapes, the higher the Resveratrol content of the wine. Red wine is full of naturally-occurring Resveratrol. Studies have shown promise that something in the wine held the answer…


The “French Paradox” lies in the fact that although the French regularly consume rich, fatty foods, smoke cigarettes and consume a higher amount of alcohol than most Americans—they have a far lower rate of heart disease and other related health issues. Some believe that the antioxidant-rich, protective plant compound Resveratrol (from the skin of the grapes in the red wine the French drink) just might be the missing piece to the puzzle.

  1. ABC News 60 MinutesFountain of Youth in a Wine Rx? 2009 May 24 ePub.
  2. Yang DL, Zhang HG, Xu YL, Gao YH, Yang XJ, Hao XQ, Li XH. Resveratrol Inhibits Right Ventricular Hypertrophy Induced By Monocrotaline In Rats.  ClinExp Pharmacol Physiol. 2009 Jun 29. Epub
  3. Albani D, Polito L, Batelli S, De Mauro S, Fracasso C, Martelli G, Colombo L, Manzoni C, Salmona M, Caccia S, Negro A, Forloni G. The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide.J Neurochem. 2009 Jun 22. Epub
  4. Presta MA, Bruyneel B, Zanella R, Kool J, Krabbe JG, Lingeman H. Determination of Flavonoids and Resveratrol in Wine by Turbulent-Flow Chromatography-LC-MS.Chromatographia. 2009 Jun;69 (Suppl 2):167-173. Epub 2009 May 26.
  5. Berrougui H, Grenier G, Loued S, Drouin G, Khalil A. A new insight into resveratrol as an atheroprotective compound: Inhibition of lipid peroxidation and enhancement of cholesterol efflux. Atherosclerosis. (2009, May 22) Epub.
  6. Marques FZ, Markus MA, Morris BJ. Resveratrol: Cellular actions of a potent natural chemical that confers a diversity of health benefits. Int J Biochem Cell Biol. 2009 Jun 13. Epub.
  7. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Resveratrol improves health and survival of mice on a high-calorie diet.Nature. 2006 Nov 16;444(7117):337-42. Epub 2006 Nov 1.
  8. Sanders TH, McMichael RW. Occurrence of resveratrol in edible peanuts. Presentation, American Oil Chemists Society, Las Vegas, Nevada, 1998. Discussed in Peanuts contain significant amount of plant compound that may prevent risk of heart disease and cancer, a news release from The Peanut Institute, Sept 8, 1998.
  9. Chanvitayapongs S, Draczynska-Lusiak B, Sun AY. Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells. Neuroreport 8:1499-1502, 1997.
  10. Kopp P. Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'? European Journal of Endocrinology 138:619-620, 1998.


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